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Categorization [ edit ]
A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in💪 humans.[2] This nomenclature system is defined by a designation that is composed of the first three letters of the genus;💪 a space; the first letter of the species name; a space and an Arabic number. In the event that two💪 species names have identical designations, they are discriminated from one another by adding one or more letters (as necessary) to💪 each species designation.
The allergens in this family include allergens with the following designations: Bet v 1, Dau c 1, and💪 Pru a 1. Other proteins belonging to this family include the major pollen allergens:
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NMR analysis[3] has confirmed💪 earlier predictions of the protein structure and site of the major T-cell epitope.[4] The Bet v 1 protein comprises 6💪 anti-parallel beta-strands and 3 alpha-helices. Four of the strands dominate the global fold, and 2 of the helices form a💪 C-terminal amphipathic helical motif. This motif is believed to be the T-cell epitope. However, one very striking feature of the💪 three-dimensional structure of Bet v 1 is the presence of a large hydrophobic cavity, which is open to the exterior💪 and probably functions as a ligand binding site.[5]
The motif is also found in:
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